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Bất kỳ loại thuốc có khả năng làm điều tốt cũng có khả năng làm tổn hại, và phản ứng không mong muốn có thể rất bất ngờ. Một số các phản ứng bất lợi liên quan đến liều, nhưng những người khác là mang phong cách riêng. | Adverse reactions and overtreatment Adverse reactions Any drug capable of doing good is also capable of doing harm and unwanted reactions can be very unexpected. Some of these adverse reactions are dose related but others are idiosyncratic. Problems may relate to the drug s main pharmacological action in the body or to some secondary action side effect . The recognition of these adverse reactions is of vital importance but their proper documentation and reporting is frequently neglected. The Committee on Safety of Medicines CSM operates a simple yellow lettercard reporting system in the UK for the Medicines and Healthcare Regulatory Agency that is designed to make it easier for staff to initiate such notifications. Copies of the prepaid lettercard can be found bound into the back of each new edition of the British National Formulary. The Committee has its main base in London tel 0800 731 6789 but there are also five other regional reporting centres see box below . Doctors have a professional duty to report all serious suspected reactions even if they are already well recognised especially if they are fatal life-threatening disabling or incapacitating. This is necessary so that reports can be prepared comparing the risk benefit ratio seen with other drugs of a similar class. Doctors should also report any adverse or unexpected event however minor where this could conceivably be a response to a drug that has only been on the market for a relatively short time. Pharmacists also have a responsibility to report all important adverse reactions coming to their attention. Nurses and midwives are often the first to suspect an adverse reaction they have a duty to see that any such reaction is brought to the attention of the appropriate doctor or pharmacist and to initiate a report themselves if necessary. Deaths have by law to be reported to the coroner. The CSM are interested in hearing about adverse reactions caused by anytherapeutic agent including any drug blood product
