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Eukaryotic cells have to regulate peroxisomal metabolism to meet their environmental or developmental requirements. Therefore, the control of peroxisome number, which is mediated not only by proliferation but also by degradation, is an important cellular event. Here we briefly review stud-ies on the autophagic degradation of peroxisomes, a process now termed pexophagy. | MINIREVIEW Peroxisomes as dynamic organelles autophagic degradation Masahide Oku1 and Yasuyoshi Sakai1 2 1 Division of Applied Life Sciences Graduate Schoolof Agriculture Kyoto University Japan 2 CREST Japan Science and Technology Agency Tokyo Japan Keywords autophagy lysosome organelle turnover peroxisomes protein degradation vacuole Correspondence Y. Sakai Division of Applied Life Sciences Graduate Schoolof Agriculture Kyoto University Kitashirakawa-Oiwake Sakyo Kyoto 606-8502 Japan Fax 81 75 753 6454 Tel 81 75 753 6385 E-mail ysakai@kais.kyoto-u.ac.j.p Received 18 January 2010 revised 20 May 2010 accepted 2 June 2010 Eukaryotic cells have to regulate peroxisomal metabolism to meet their environmental or developmental requirements. Therefore the control of peroxisome number which is mediated not only by proliferation but also by degradation is an important cellular event. Here we briefly review studies on the autophagic degradation of peroxisomes a process now termed pexophagy. Recent advances in molecular analyses of both nonselective and selective autophagic pathways have revealed a category of autophagy-related genes ATG many of which are shared in different pathways. In this review we introduce the functions of the shared ATG products along with their interactions with peroxisomal factors. Physiological functions of this process especially cellular remodeling in mammalian cells and in a phytopathogenic fungus are also introduced. doi 10.1111 j.1742-4658.2010.07741.x Introduction The dynamic nature of peroxisomes is supported by various molecular mechanisms of organelle biogenesis augmentation and degradation. In this review we focus on the mechanism of autophagic degradation of this organelle. Studies on another aspect of peroxisome dynamics i.e. peroxisome biogenesis are elaborately reviewed in the review by Wolf et al. in this miniseries 1 . In addition a comprehensive review on peroxisome dynamics in yeast experimental systems can be found in this .
