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Management of Complications of Chronic Liver Disease: “When to Refer to Transplant?”

Only one randomized trial, the Multicenter Study of Hydroxyurea for Sickle Cell Anemia (MSH Study), tested the efficacy of hydroxyurea in adults with sickle cell anemia, with six additional analyses either based on this trial or on followup studies. The significant hematological effects of hydroxyurea after 2 years (as compared to the placebo arm) included a small mean increase of 0.6 g/dl in total hemoglobin and a moderate absolute increase in fetal hemoglobin of 3.2 percent. The median number of painful crises was 44 percent lower, and the time to the first painful crisis was 3 months, as compared. | Management of Complications I of Chronic L iVer- Disease 4r When to Refer to Transplant Philip Rosenthal M.D. Professor of Pediatrics Surgery UniveiStyof California . San Francisco THE LIVER Largest organ in body RUQ of abdomen Sheltered by rib cage In adult weighs 3 lbs. LIVER GROSS ANATOMY Separated into 2 lobes Right and Left Right lobe is 6X larger than the left Porta hepatis is entry site for blood vessels and exit site for bile .