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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Psychometric validation of the Dutch translation of the quality of life in reflux and dyspepsia (QOLRAD) questionnaire in patients with gastroesophageal reflux disease | Engels et al. Health and Quality of Life Outcomes 2010 8 85 http www.hqlo.eom content 8 1 85 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Psychometric validation of the Dutch translation of the quality of life in reflux and dyspepsia QOLRAD questionnaire in patients with gastroesophageal reflux disease Leopold GJB Engels1 Elly C Klinkenberg-Knol2 Jonas Carlsson3 Katarina Hailing3 4 5 Abstract Background The Quality of Life in Reflux and Dyspepsia QOLRAD questionnaire is one of the best-characterized disease-specific instruments that captures health-related problems and symptom-patterns in patients with gastroesophageal reflux disease GERD . This paper reports the psychometric validation of a Dutch translation of the QOLRAD questionnaire in gastroenterology outpatients with GERD. Methods Patients completed the QOLRAD questionnaire at visit 1 baseline visit 2 after 2 4 or 8 weeks of acute treatment with esomeprazole 40 mg once daily and visit 4 after 6 months with on-demand esomeprazole 40 mg once daily or continuous esomeprazole 20 mg once daily . Symptoms were assessed at each visit and patient satisfaction was assessed at visits 2 and 4. Results Of the 1166 patients entered in the study 97.3 had moderate or severe heartburn and 55.5 had moderate or severe regurgitation at baseline. At visit 2 symptoms of heartburn and regurgitation were mild or absent in 96.7 and 97.7 respectively and 95.3 of patients reported being satisfied with the treatment. The internal consistency and reliability of the QOLRAD questionnaire range 0.83-0.92 supported construct validity. Convergent validity was moderate to low. Known-groups validity was confirmed by a negative correlation between the QOLRAD score and clinician-assessed severity of GERD symptoms. Effect sizes 1.15-1.93 and standardized response means 1.17-1.86 showed good responsiveness to change. GERD symptoms had a negative impact on patients lives. Conclusions The psychometric characteristics of the Dutch .
