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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey | Budzynski et al. Health and Quality of Life Outcomes 2011 9 77 http www.hqlo.eom content 9 1 77 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind placebo-controlled trial of the SF-36 survey 1.2 2 2 2 2 1.3 Jacek Budzynski 1 Grzegorz Pulkowski Karol Suppan Jacek Fabisiak Marcin Majer Maria KJopocka 1 Beata Galus-Pulkowska4 and Marcin Wasielewski2 Abstract Background Many patients with coronary artery disease CAD have overlapping gastroenterological causes of recurrent chest pain mainly due to gastroesophageal reflux GER and aspirin-induced gastrointestinal tract damage. These symptoms can be alleviated by proton pump inhibitors PPIs . The study addressed whether omeprazole treatment also affects general health-related quality of life HRQL in patients with CAD. Study 48 patients with more than 50 narrowing of the coronary arteries on angiography without clinically overt gastrointestinal symptoms were studied. In a double-blind placebo-controlled cross-over study design patients were randomized to take omeprazole 20 mg bid or a placebo for two weeks and then crossed over to the other study arm. The SF-36 questionnaire was completed before treatment and again after two weeks of therapy. Results Patients treated with omeprazole in comparison to the subjects taking the placebo had significantly greater values for the SF-36 survey which relates to both physical and mental health as well as for bodily pain general health perception and physical health. In comparison to the baseline values therapy with omeprazole led to a significant increase in the three summarized health components total SF-36 physical and mental health and in the following detailed health concept scores physical functioning limitations due to physical health problems bodily pain and emotional well-being. Conclusions A double dose
