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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities Skirmantas Janusonis Address Yale University School of Medicine Department of Neurobiology P.O. Box 208001 New Haven CT 06520-8001 USA Email Skirmantas Janusonis - skirmantas.janusonis@yale.edu Corresponding author Published 19 July 2005 Received 09 March 2005 Theoretical Biology and Medical Modelling 2005 2 27 doi 10.1186 1742-4682-2-27 Accepted 19 July 2005 This article is available from http www.tbiomed.cOm content 2 1 27 2005 Janusonis licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A wide range of abnormalities has been reported in autistic brains but these abnormalities may be the result of an earlier underlying developmental alteration that may no longer be evident by the time autism is diagnosed. The most consistent biological finding in autistic individuals has been their statistically elevated levels of 5-hydroxytryptamine 5-HT serotonin in blood platelets platelet hyperserotonemia . The early developmental alteration of the autistic brain and the autistic platelet hyperserotonemia may be caused by the same biological factor expressed in the brain and outside the brain respectively. Unlike the brain blood platelets are short-lived and continue to be produced throughout the life span suggesting that this factor may continue to operate outside the brain years after the brain is formed. The statistical distributions of the platelet 5-HT levels in normal and autistic groups have characteristic features and may contain information about the nature of this yet unidentified factor. Results The identity of this factor was studied
