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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effect of 28 days of creatine ingestion on muscle metabolism and performance of a simulated cycling road race | Hickner et al. Journal of the International Society of Sports Nutrition 2010 7 26 http www.jissn.eom content 7 1 26 jissn journal of the international society of sports nutrition RESEARCH ARTICLE Open Access EffeCCt of 28 days of creatine ingestion on muscle metabolism and performance of a simulated cycling road race Robert C Hickner 1 2 David J Dyck3 Josh Sklar1 Holly Hatley1 and Priscilla Byrd1 Abstract Purpose The effects of creatine supplementation on muscle metabolism and exercise performance during a simulated endurance road race was investigated. Methods Twelve adult male 27.3 1.0 yr 178.6 1.4 cm 78.0 2.5 kg 8.9 1.1 fat endurance-trained 53.3 2.0 ml kg-1 min-1 cycling 160 km wk cyclists completed a simulated road race on a cycle ergometer Lode consisting of a two-hour cycling bout at 60 of peak aerobic capacity VO2peak with three 10-second sprints performed at 110 VO2 peak every 15 minutes. Cyclists completed the 2-hr cycling bout before and after dietary creatine monohydrate or placebo supplementation 3 g day for 28 days . Muscle biopsies were taken at rest and five minutes before the end of the two-hour ride. Results There was a 24.5 10.0 increase in resting muscle total creatine and 38.4 23.9 increase in muscle creatine phosphate in the creatine group P 0.05 . Plasma glucose blood lactate and respiratory exchange ratio during the 2hour ride as well as VO2 peak were not affected by creatine supplementation. Submaximal oxygen consumption near the end of the two-hour ride was decreased by approximately 10 by creatine supplementation P 0.05 . Changes in plasma volume from pre- to post-supplementation were significantly greater in the creatine group 14.0 6.3 than the placebo group -10.4 4.4 P 0.05 at 90 minutes of exercise. The time of the final sprint to exhaustion at the end of the 2-hour cycling bout was not affected by creatine supplementation creatine pre 64.4 13.5s creatine post 88.8 24.6s placebo pre 69.0 24.8s placebo post 92.8 31.2s creatine vs. .
