Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Sepsis biomarkers: a review. | Pierrakos and Vincent Critical Care 2010 14 R15 http ccforum.eom content 14 1 R15 c CRITICAL CARE RESEARCH Open Access Sepsis biomarkers a review Charalampos Pierrakos Jean-Louis Vincent Abstract Introduction Biomarkers can be useful for identifying or ruling out sepsis identifying patients who may benefit from specific therapies or assessing the response to therapy. Methods We used an electronic search of the PubMed database using the key words sepsis and biomarker to identify clinical and experimental studies which evaluated a biomarker in sepsis. Results The search retrieved 3370 references covering 178 different biomarkers. Conclusions Many biomarkers have been evaluated for use in sepsis. Most of the biomarkers had been tested clinically primarily as prognostic markers in sepsis relatively few have been used for diagnosis. None has sufficient specificity or sensitivity to be routinely employed in clinical practice. PCT and CRP have been most widely used but even these have limited ability to distinguish sepsis from other inflammatory conditions or to predict outcome. Introduction Sepsis is a leading cause of death in critically ill patients despite the use of modern antibiotics and resuscitation therapies 1 . The septic response is an extremely complex chain of events involving inflammatory and antiinflammatory processes humoral and cellular reactions and circulatory abnormalities 2 3 . The diagnosis of sepsis and evaluation of its severity is complicated by the highly variable and non-specific nature of the signs and symptoms of sepsis 4 . However the early diagnosis and stratification of the severity of sepsis is very important increasing the possibility of starting timely and specific treatment 5 6 . Biomarkers can have an important place in this process because they can indicate the presence or absence or severity of sepsis 7 8 and can differentiate bacterial from viral and fungal infection and systemic sepsis from local infection. Other potential uses of
