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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Statin research in critical illness: hampered by poor trial design? | Available online http ccforum.eom content 13 6 1015 Commentary Statin research in critical illness hampered by poor trial design Marius Terblanche1 and Neill KJ Adhikari2 1 Department of Critical Care Medicine Guy s and St Thomas NHS Foundation Trust London UK 2Department of Critical Care Medicine Sunnybrook Health Sciences Centre University of Toronto Toronto Ontario Canada Correspondence to Marius Terblanche Marius.terblanche@gstt.nhs.uk See related research by Morgan et al. http ccforum.com content 13 5 R165 Published 11 December 2009 This article is online at http ccforum.com content 13 6 1015 2009 BioMed Central Ltd Critical Care 2009 13 1015 doi 10.1186 cc8173 Abstract Statin therapy may prevent an excessive inflammatory response after cardiopulmonary bypass for cardiac surgery. In a recent issue of Critical Care Morgan and colleagues present data from a well-conducted systematic review and meta-analysis of randomised controlled trials using inflammatory markers as primary outcome measure. They find that pre-operative statin therapy compared with placebo may reduce various post-operative markers of systemic inflammation IL-6 IL-8 C-reactive protein tumour necrosis factor-alpha . Their ability to make definitive conclusions is limited however by the suboptimal methodological quality of the primary studies. Their review suggests that ICU researchers should focus on developing valid surrogate markers and use these to accurately describe the mechanisms and effectiveness of novel therapies before proceeding to large pragmatic trials using mortality as primary outcome. In a recent issue of Critical Care Morgan and colleagues present the results of a well-conducted systematic review and meta-analysis of the effect of statin therapy on inflammatory markers after cardiac surgery 1 . Observational evidence suggests that statin therapy may dampen the inflammatory response following exposure to a significant trigger and there is currently much interest in using statins .
