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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Functional relevance of IL-10 promoter polymorphisms for sepsis development. | Stanilova Critical Care 2010 14 119 http ccforum.eom content 14 1 119 CRITICAL CARE COMMENTARY L__ Functional relevance of IL-10 promoter polymorphisms for sepsis development Spaska A Stanilova See related research by Zeng etal. http ccforum.eom content 13 6 R188 Abstract The induced production of proinflammatory and anti-inflammatory cytokines is considered important for the development of sepsis and its sequelae. Polymorphisms in the IL-10 gene promoter could influence its expression and sepsis susceptibility. Results obtained by Dr Ling and colleagues demonstrated that the -1082A allele was significantly associated with lower lipopolysaccharide-induced IL-10 production in an allele-dose-dependent fashion. They also showed that this polymorphism was significantly associated with sepsis development after major trauma. These and other research data clearly demonstrated that the -1082 A G polymorphism in the IL-10 gene promoter has an important impact on susceptibility of sepsis and sepsis outcome. Dr Ling and colleagues performed a large prospective study including 308 patients with major trauma and determined that the genotype distribution of the IL-10 polymorphisms was associated with the sepsis morbidity rate and multiple organ dysfunction syndrome MODS scores 1 . The authors also investigated the association of polymorphisms with lipopolysaccharide-induced IL-10 production. Cytokine production varies between individuals due to genetic background and certain allelic variants of cytokine genes - in particular SNPs are associated with higher or lower cytokine production. The IL-10 5 -flanking region which controls transcription is polymorphic with two microsatellites and three SNPs -1082 -819 and -592 2 . Polymorphisms in the regulatory region of the IL-10 gene may influence its expression and hence could influence the susceptibility of sepsis 3 . Correspondence stanilova@mf.uni-sz.bg Department of Molecular Biology Immunology Medical Genetics Faculty of
