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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Paget's disease of the skull causing hyperprolactinemia and erectile dysfunction: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Paget s disease of the skull causing hyperprolactinemia and erectile dysfunction a case report Rachel Hepherd1 and Paul E Jennings 2 Address 1ST2 Core Medical Training Hull Royal Infirmary Anlaby Road Hull HU3 2JZ UK and 2York Hospital Wigginton Road York YO31 8HE UK Email Rachel Hepherd - rachelhepherd@hotmail.com Paul E Jennings - paul.e.jennings@york.nhs.uk Corresponding author Published 18 July 2008 Received 12 October 2007 Journal of Medical Case Reports 2008 2 234 doi 10.1186 1752-1947-2-234 Accepted 18 July 2008 This article is available from http www.jmedicalcasereports.cOm content 2 1 234 2008 Hepherd and Jennings licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Hyperprolactinemia is an uncommon cause of erectile dysfunction in men. Paget s disease of the skull is a relatively common disease. This case proposes a rare example of a causative link between the two and how treatment of the Paget s disease with bisphosphonates helped the patient regain erectile function. Case presentation A 67-year-old man with Paget s disease of the skull presented with prostatitis erectile dysfunction and hyperprolactinemia. Radio-isotope scanning showed increased vascularity around the sphenoid bone. Treatment with intravenous bisphosphonates improved the active Paget s disease as indicated by declining alkaline phosphatase levels and the patient s erectile function while serum prolactin levels became normal and serum testosterone levels remained unchanged. Conclusion It is possible that hyperprolactinemia is unrecognised in other patients with Paget s disease of
