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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Decrease in tobacco consumption after treatment with topiramate and aripiprazole: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Decrease in tobacco consumption after treatment with topiramate and aripiprazole a case report Beatriz Arbaizar1 Inés Gómez-Acebo2 3 and Javier Llorca 2 3 Address Unit of Mental Health Hospital de Laredo Laredo Spain 2CIBER en Epidemiología y Salud Pública CIBERESP Spain and 3Group of Epidemiology and Computational Biology University of Cantabria Santander Spain Email BeatrizArbaizar-barbaizar@hlrd.scsalud.es Inés Gómez-Acebo - inesgomezacebo@ono.com Javier Llorca - llorcaj@unican.es Corresponding author Published II June 2008 Received 28 November 2007 Journal of Medical Case Reports 2008 2 198 doi 10.1186 1752-1947-2-198 Accepted 11 June 2008 This article is available from http www.jmedicalcasereports.com content 2 I I98 2008 Arbaizar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction A large part of research into drug addiction focuses on mesolimbic dopamine circuitry however both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and or kainate and dopamine D2 receptors can play a role in maintaining the established addiction. Case presentation We report the case of a 34-year-old man who compulsively smoked 80 to 100 cigarettes each day. After receiving treatment with topiramate and aripiprazole his tobacco consumption was dramatically reduced. Conclusion Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and or kainate blocking agents and a dopamine D2 receptor partial agonist may be novel instruments for nicotine abuse disorders. Introduction It is generally considered that the effect of drugs of abuse is focused towards mesolimbic dopamine DA reward circuitry this is formed by the ventral tegmental area which .
