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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Increased cardiac index due to terbutaline treatment aggravates capillary-alveolar macromolecular leakage in oleic acid lung injury in dogs. | Available online http ccforum.eom content 13 5 R166 Research Increased cardiac index due to terbutaline treatment aggravates capillary-alveolar macromolecular leakage in oleic acid lung injury in dogs Raphael Briot Sam Bayat Daniel Anglade Jean-Louis Martiel and Francis Grimbert Laboratoire TIMC Equipe PRETA Unite Mixte de Recherche 5525 du Centre National de Recherche Scientifique Université Joseph Fourier Centre Hospitalier Universitaire Grenoble 38043 cedex 09 France Corresponding author Raphael Briot rbriot@chu-grenoble.fr Received 2 Sep 2009 Revisions requested 23 Sep 2009 Revisions received 30 Sep 2009 Accepted 21 Oct 2009 Published 21 Oct 2009 Critical Care 2009 13 R166 doi 10.1186 cc8137 This article is online at http ccforum.com content 13 5 R1 66 2009 Briot et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction We assessed the in vivo effects of terbutaline a beta2-agonist assumed to reduce microvascular permeability in acute lung injury. Methods We used a recently developed broncho-alveolar lavage BAL technique to repeatedly measure every 15 min. for 4 hours the time-course of capillary-alveolar leakage of a macromolecule fluorescein-labeled dextran in 19 oleic acid OA lung injured dogs. BAL was performed in a closed lung sampling site using a bronchoscope fitted with an inflatable cuff. Fluorescein-labeled Dextran FITC-D70 was continuously infused and its concentration measured in plasma and BAL fluid. A two-compartment model blood and alveoli was used to calculate KAB the transport rate coefficient of FITC-D70 from blood to alveoli. KAB was estimated every 15 minutes over 4 hours. Terbutaline intra-venous perfusion was started 90 min. after the onset of the injury and then .
