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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose | Theoretical Biology and Medical Modelling BioMed Central Research Open Access A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose Anthony J Chalmers 1 Soeren M Bentzen2 and Francesca M Buffa3 Address 1Brighton and Sussex Medical School University of Sussex Falmer Brighton BN1 9RQ UK 2University of Wisconsin Medical School Department of Human Oncology K4 316 Clinical Sciences Center 600 Highland Avenue Madison WI 53792 USA and 3Cancer Research UK Molecular Oncology Laboratories Weatherall Institute of Molecular Medicine University of Oxford John RadcliffeHospital Oxford OX3 9DU UK Email Anthony J Chalmers - a.j.chalmers@sussex.ac.uk Soeren M Bentzen - bentzen@humonc.wisc.edu Francesca M Buffa - francesca.buffa@molecular-medicine.oxford.ac.uk Corresponding author Published 19 July 2007 Theoretical Biology and Medical Modelling 2007 4 25 doi 10.1186 1742-4682-4-25 Received 26 April 2007 Accepted 19 July 2007 This article is available from http www.tbiomed.cOm content 4 1 25 2007 Chalmers et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Purpose Current methods for quantifying effects of DNA repair modifiers on radiation sensitivity assume a constant effect independent of the radiation dose received. The aim of this study was to develop and evaluate a modelling strategy by which radiation dose dependent effects of DNA repair inhibitors on clonogenic survival might be identified and their significance assessed. Methods An indicator model that allowed quantification of the Sensitiser Effect on Radiation response as a function of Dose SERD was developed. This model was fitted to clonogenic survival data derived from human tumour and rodent fibroblast
