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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Measuring the functional sequence complexity of proteins | Theoretical Biology and Medical Modelling BioMed Central Research Measuring the functional sequence complexity of proteins Kirk K Durston 1 David KY Chiu2 David L Abel3 and Jack TTrevors4 Address 1 Department of Biophysics University of Guelph Guelph ON N1G 2W1 Canada 2Department of Computing and Information Science University of Guelph Guelph ON N1G 2W1 Canada 3Program Director The Gene Emergence Project The Origin-of-Life Foundation Inc. 113 Hedgewood Drive Greenbelt MD 20770-1610 USA and 4Department of Environmental Biology University of Guelph Guelph ON N1G 2W1 Canada Email Kirk K Durston - kdurston@uoguelph.ca David KY Chiu - dchiu@snowhite.cis.uoguelph.ca David L Abel - life@us.net Jack T Trevors - jtrevors@uoguelph.ca Corresponding author Open Access Published 6 December 2007 Received 25 January 2007 Acce ted 6 December 2007 Theoretical Biology and Medical Modelling 2007 4 47 doi 10.1186 1742-4682-4-47 p This article is available from http www.tbiomed.cOm content 4 1 47 2007 Durston et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Abel and Trevors have delineated three aspects of sequence complexity Random Sequence Complexity RSC Ordered Sequence Complexity OSC and Functional Sequence Complexity FSC observed in biosequences such as proteins. In this paper we provide a method to measure functional sequence complexity. Methods and Results We have extended Shannon uncertainty by incorporating the data variable with a functionality variable. The resulting measured unit which we call Functional bit Fit is calculated from the sequence data jointly with the defined functionality variable. To demonstrate
