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Báo cáo y học: "Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients. | Available online http ccforum.eom content 13 3 R95 Research Serum resistin levels in critically ill patients are associated with inflammation organ dysfunction and metabolism and may predict survival of non-septic patients Alexander Koch1 Olav A Gressner2 Edouard Sanson1 Frank Tacke1 and Christian Trautwein1 Open Access Department of Medicine III RWTH-University Hospital Aachen Pauwelsstrasse 30 52074 Aachen Germany institute of Clinical Chemistry and Pathobiochemistry RWTH-University Hospital Aachen Pauwelsstrasse 30 52074 Aachen Germany Contributed equally Corresponding author Alexander Koch akoch@ukaachen.de Received 2 Apr 2009 Revisions requested 14 May 2009 Revisions received 27 May 2009 Accepted 19 Jun 2009 Published 19 Jun 2009 Critical Care 2009 13 R95 doi 10.1186 cc7925 This article is online at http ccforum.com content 13 3 R95 2009 Koch et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Blood glucose levels and insulin resistance in critically ill patients on admission to intensive care units ICUs have been identified as factors influencing mortality. The pathogenesis of insulin resistance IR in critically ill patients is complex and not fully understood. Resistin is a hormone mainly derived from macrophages in humans and from adipose tissue in rodents which regulates glucose metabolism and insulin sensitivity. In non-critically ill patients resistin was found to be related to impaired glucose tolerance insulin resistance metabolic syndrome obesity and type 2 diabetes. Therefore resistin might represent a link between inflammation acute phase response and insulin resistance in critically ill patients. We aimed to examine the correlation of serum resistin concentrations to parameters of .