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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. | Available online http ccforum.eom content 13 3 R75 Open Access Research Dexmedetomidine vs. haloperidol in delirious agitated intubated patients a randomised open-label trial Michael C Reade Kim O Sullivan Samantha Bates Donna Goldsmith William RSTJ Ainslie and Rinaldo Bellomo Department of Intensive Care Medicine Austin Hospital and the University of Melbourne 145 Studley Road Heidelberg Victoria 3084 Australia Corresponding author Michael C Reade Michael.READE@austin.org.au Received 27 Feb 2009 Revisions requested 25 Mar 2009 Revisions received 13 May 2009 Accepted 19 May 2009 Published 19 May 2009 Critical Care 2009 13 R75 doi 10.1186 cc7890 This article is online at http ccforum.com content 13 3 R75 2009 Reade et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Agitated delirium is common in patients undergoing mechanical ventilation and is often treated with haloperidol despite concerns about safety and efficacy. Use of conventional sedatives to control agitation can preclude extubation. Dexmedetomidine a novel sedative and anxiolytic agent may have particular utility in these patients. We sought to compare the efficacy of haloperidol and dexmedetomidine in facilitating extubation. Methods We conducted a randomised open-label parallel-groups pilot trial in the medical and surgical intensive care unit of a university hospital. Twenty patients undergoing mechanical ventilation in whom extubation was not possible solely because of agitated delirium were randomised to receive an infusion of either haloperidol 0.5 to 2 mg hour or dexmedetomidine 0.2 to 0.7 pg kg hr with or without loading doses of 2.5 mg haloperidol or 1 pg kg dexmedetomidine according to clinician preference. Results .
