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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Anti-oxidative effects of the biennial flower of Panax notoginseng against . | Choi et al. Chinese Medicine 2010 5 38 http www.cmjournal.Org content 5 1 38 CHINESE MEDICINE RESEARCH Open Access Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells 1 1.2 1 1 1 z- I- 1 Roy Chi-Yan Choi Zhiyong Jiang Heidi Qun Xie Anna Wing-Han Cheung David Tai-Wai Lau Qiang Fu Tina Tingxia Dong1 Jijun Chen2 Zhengtao Wang3 Karl Wah-Keung Tsim1 Abstract Background Radix notoginseng is used in Chinese medicine to improve blood circulation and clotting however the pharmacological activities of other parts of Panax notoginseng have yet to be explored. The present study reports the anti-oxidative effects of various parts of Panax notoginseng. Methods Various parts of Panax notoginseng including the biennial flower stem-leaf root-rhizome fiber root and sideslip were used to prepare extracts and analyzed for their anti-oxidation effects namely suppressing xanthine oxidase activity H2O2-induced cytotoxicity and H2O2-induced ROS formation. Results Among various parts of the herb biennial flower stem-leaf root-rhizome fiber root and sideslip the water extract of the biennial flower showed the strongest effects in i inhibiting the enzymatic activity of xanthine oxidase and ii protecting neuronal PC12 cells against H2O2-induced cytotoxicity. Only the water extracts demonstrated such anti-oxidative effects while the ethanol extracts did not exert significant effects in suppressing xanthine oxidase and H2O2-induced neuronal cytotoxicity. Conclusions The present study demonstrates the biennial flower of Panax notoginseng to have neuroprotection effect on cultured neurons and the underlying protection mechanism may involve anti-oxidation. Background Radix Notoginseng Sanqi the root of Panax notogin-seng is a Chinese herbal medicine used in China to promote blood circulation remove blood stasis induce blood clotting relieve swelling and alleviate pain 1 2 . Moreover Panax notoginseng is beneficial for coronary