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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats. | Feng et al. Chinese Medicine 2010 5 33 http www.cmjournal.Org content 5 1 33 CHINESE MEDICINE RESEARCH Open Access Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats 1 1 1 1 2 2 -I- 1 Yibin Feng Ka-Yu Siu Xingshen Ye Ning Wang Man-Fung Yuen Chung-Hang Leung Yao Tong Seiichi Kobayashi4 Abstract Background Berberine is an active compound in Coptidis Rhizoma Huanglian with multiple pharmacological activities including antimicrobial antiviral anti-inflammatory cholesterol-lowering and anticancer effects. The present study aims to determine the hepatoprotective effects of berberine on serum and tissue superoxide dismutase SOD levels the histology in tetrachloride CCl4 -induced liver injury. Methods Sprague-Dawley rats aged seven weeks were injected intraperitoneally with 50 CCl4 in olive oil. Berberine was orally administered before or after CCl4 treatment in various groups. Twenty-four hours after CCl4 injection serum alanine aminotransferase ALT and aspartate aminotransferase AST activities serum and liver superoxide dismutase SOD activities were measured. Histological changes of liver were examined with microscopy. Results Serum ALT and AST activities significantly decreased in a dose-dependent manner in both pre-treatment and post-treatment groups with berberine. Berberine increased the SOD activity in liver. Histological examination showed lowered liver damage in berberine-treated groups. Conclusion The present study demonstrates that berberine possesses hepatoprotective effects against CCl4-induced hepatotoxicity and that the effects are both preventive and curative. Berberine should have potential for developing a new drug to treat liver toxicity. Background Liver damage induced by carbon tetrachloride CCl4 involves biotransformation of free radical derivatives increased lipid peroxidation and excessive cell death in liver tissue 1 2 . This model of CCl4-induced liver injury has been widely used in new drug .
