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The expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple bio-logical aspects, including neural development, stress response and neurode-generative diseases. | MINIREVIEW Acetylcholinesterase in cell adhesion neurite growth and network formation Laura E. Paraoanu and Paul G. Layer Darmstadt University of Technology Germany Keywords acetylcholinesterase adhesion co-opting proteins extracellular matrix knock-out mouse neurite outgrowth non-cholinergic functions laminin-1 retina structural interactions Correspondence L. E. Paraoanu Darmstadt University of Technology DevelopmentalBiology Schnittspahnstrasse 3 64287 Darmstadt Germany Fax 49 6151 166548 Tel 49 6151 166105 E-mail paraoanu@bio.tu-darmstadt.de Received 27 September 2007 accepted 22 November 2007 The expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple biological aspects including neural development stress response and neurode-generative diseases. Therefore the classical function of acetylcholinesterase has to be distinguished from its non-classical e.g. enzymatic from non-enzymatic functions. Here the roles of acetylcholinesterase in cell adhesion promoting neurite outgrowth and neural network formation are reviewed briefly together with potential mechanisms to support these functions. Part of these functions may depend on the structural properties of acetylcholinesterase for example protein-protein interactions. Recent findings have revealed that laminin-1 is an interaction partner for acetylcholinesterase. The binding of acetylcholinesterase to this extracellular matrix component may allow cell-to-cell recognition and also cell signalling via membrane receptors. Studies using monolayer and 3D spheroid retinal cultures as well as the acetylcholinesterase-knockout mouse have been instrumental in elaborating the non-classical functions of acetylcholinesterase. doi 10.1111 j.1742-4658.2007.06237.x Acetylcholinesterase - a protein with many faces Acetylcholinesterase EC 3.1.1.7 is an enzyme that has an indispensable role in synaptic transmission by catalysing hydrolysis of the .
