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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: CpG Immunotherapy in Chenopodium album sensitized mice: The comparison of IFN-gamma, IL-10 and IgE responses in intranasal and subcutaneous administrations. | Clinical and Molecular Allergy BioMed Central Research CpG Immunotherapy in Chenopodium album sensitized mice The comparison of IFN-gamma IL-10 and IgE responses in intranasal and subcutaneous administrations Tahereh Mousavi 1 Nader Tajik1 Maziar Moradi2 and Masoomeh Fallah Radjabzadeh1 Address Department of Immunology Iran University of medical sciences Shahid Hemmat highway 14496 Tehran Iran and 2Department of Social Medicine Iran university of Medical Sciences Shahid Hemmat highway 14496 Tehran Iran Email Tahereh Mousavi - mousavi36@yahoo.com Nader Tajik - nadertajik@yahoo.com Maziar Moradi - mousavi@hotmail.com Masoomeh Fallah Radjabzadeh - nadertajik@yahoo.com Corresponding author Open Access Published 17 September 2008 Received 13 April 2008 n J _. n .1 ir Accepted 17 September 2008 Clinical and Molecular Allergy 2008 6 10 doi 10.1186 1476-7961-6-10 This article is available from http www.clinicalmolecularallergy.cOm content 6 1 10 2008 Mousavi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Mucosal-based immunotherapy has been already used as an alternative form of allergen delivery. In asthma the poor success rate of immune modulation could be a consequence of inadequate immune modulation in the airways. Previously we have found that subcutaneous S.C co-administration of a homemade allergenic extract from Chenopodium album Ch.a pollen and Guanine-Cytosine containing deoxynucleotides CpG-ODNs is effective to prevent the inflammatory responses in mouse. In this study we used CpG Ch.a for immunotherapy of Ch.a-induced asthma and compared the intranasal I.N and S.C routes of administration concerning IFN-Y IL-10 and total IgE responses. Methods Ch.a sensitized mice were treated intranasaly
