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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils. | Clinical and Molecular Allergy BioMed Central Research Open Access Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils Iain Uings11 Ilaria Puxeddu12 Vladislav Temkin2 Susan J Smith2 Dilniya Fattah1 Keith P Ray1 and Francesca Levi-Schaffer 2 Address 1Cell Biology Unit Glaxo Wellcome SKB Gunnels Wood Stevenage Herts SG1 2NY UK and 2Department of Pharmacology School of Pharmacy The Hebrew University of Jerusalem Jerusalem Israel Email Iain Uings - iju44964@gsk.com Ilaria Puxeddu - ilarip@yahoo.it VladislavTemkin - v-temkin@northwestern.edu Susan J Smith - susan.smith@imperial.ac.uk Dilniya Fattah - dilniya.7.fattah@gsk.com Keith P Ray- kpr0136@gsk.com Francesca Levi- Schaffer -fls@cc.huji.ac.il Corresponding author fEqual contributors Published 27 April 2005 Received 11 January 2005 Clinical and Molecular Allergy 2005 3 5 doi 10.1186 1476-7961-3-5 Accepted 27 April 2005 This article is available from http www.clinicalmolecularallergy.cOm content 3 1 5 2005 Uings et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Summary Background TNF-alpha is an important mediator in allergy also for its effects on eosinophils. Methods The effect of dexamethasone on TNF-alpha induced eosinophils survival degranulation ECP cytokines release IL-8 GM-CSF and adhesion to VCAM-1 ICAM-1 and IgG coated wells EPO release were evaluated. Results The drug inhibited IL-8 and GM-CSF production but not viability degranulation or adhesion in human peripheral blood eosinophils. Conclusion These results indicate that part of the activity of glucocorticosteroids on eosinophils may be mediated by their ability to inhibit cytokine secretion that in turn is important for the perpetuation of the allergic .
