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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Expression of AFP and Rev-Erb A/Rev-Erb B and N-CoR in fetal rat liver, liver injury and liver regeneration. | Comparative Hepatology BioMed Central Research Expression of AFP and Rev-Erb A Rev-Erb B and N-CoR in fetal rat liver liver injury and liver regeneration Volker Meier Kyrylo Tron Danko Batusic Abderrahim Elmaouhoub and Giuliano Ramadori Open Access Address University of Goettingen Department of Internal Medicine Section of Gastroenterology and Endocrinology Goettingen Germany Email Volker Meier - vmeier1@gwdg.de Kyrylo Tron - ktron@gwdg.de Danko Batusic - dbatusi@gwdg.de Abderrahim Elmaouhoub - maouhou68@yahoo.de Giuliano Ramadori - gramado@med.uni-goettingen.de Corresponding author Published 05 July 2006 Received 01 July 2005 Comparative Hepatology 2006 5 2 doi 10.1186 1476-5926-5-2 Accepted 05 July 2006 This article is available from http www.comparative-hepatology.cOm content 5 1 2 2006 Meier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Alpha-fetoprotein AFP expression can resume in the adult liver under pathophysiological conditions. Orphan nuclear receptors were supposed to regulate AFP gene expression in vitro. We were interested to study the expression of AFP and orphan nuclear receptors in vivo. Results The expression of AFP gene and orphan nuclear receptors in the liver was examined in different rat models a fetal liver b liver regeneration partial hepatectomy PH with and without 2-acetyl-aminofluren treatment 2-AAF c acute liver damage treatment with CCl4 and d acute phase reaction treatment with turpentine oil . After PH of 2-AAF treated rats clusters of AFP positive cells occurred in the periportal region. In the Northern blot analysis a positive hybridization signal for the full-length AFP-RNA was .
