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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Early increases in plasminogen activator activity following partial hepatectomy in humans. | Comparative Hepatology BioMed Central Research Open Access Early increases in plasminogen activator activity following partial hepatectomy in humans David Mangnall Kirsty Smith Nigel C Bird and Ali W Majeed Address Liver Research Group Division of Clinical Sciences South K Floor Royal Hallamshire Hospital Sheffield S10 2JF UK Email David Mangnall - d.mangnall@sheffield.ac.uk Kirsty Smith - kasmith@claramail.com Nigel C Bird - n.bird@sheffield.ac.uk Ali W Majeed - a.w.majeed@sheffield.ac.uk Corresponding author Published 23 December 2004 Received 28 September 2004 Accepted 23 December 2004 Comparative Hepatology 2004 3 11 doi 10.1186 1476-5926-3-11 r This article is available from http www.comparative-hepatology.com content 3 1 11 2004 Mangnall et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Increases in urokinase-like plasminogen activator uPA activity are reported to be amongst the earliest events occurring in remnant liver following partial hepatectomy in rats and have been proposed as a key component of the regenerative response. Remodelling of the extracellular matrix conversion of single chain hepatocyte growth factor to the active two-chain form and a possible activation of a mitogenic signalling pathway have all been ascribed to the increased uPA activity. The present study aimed to determine whether similar early increases in uPA activity could be detected in the remnant liver following resection of metastatic tumours in surgical patients. Results Eighteen patients undergoing partial hepatectomy for the removal of hepatic metastases secondary to primary colonic tumours were studied. Increased plasminogen activator activity was found in the final liver samples for the group of patients in .
