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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The expanding role of Tax in transcription | Retrovirology BioMed Central Commentary The expanding role of Tax in transcription Cynthia de la Fuente2 and Fatah Kashanchi 1 2 3 Open Access Address 1Institute for Proteomics Technology and Application The George Washington University Washington DC 20037 USA 2Department of Biochemistry and Molecular Biology The George Washington University School of Medicine Washington DC 20037 USA and 3The Institute for Genomic Research TIGR Rockville MD 20850 USA Email Cynthia de la Fuente - bcmclf@gwumc.edu Fatah Kashanchi - bcmfxk@gwumc.edu Corresponding author Published 30 July 2004 Received 14 July 2004 Retrovirology 2004 1 19 doi 10.1186 1742-4690-1-19 Accepted 30 July 2004 This article is available from http www.retrovirology.cOm content 1 1 19 2004 de la Fuente and Kashanchi licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The viral transactivator of HTLV-I Tax has long been shown to target the earliest steps of transcription by forming quaternary complexes with sequence specific transcription factors and histone-modifying enzymes in the LTR of HTLV-I. However a new study suggests that Tax preferentially transactivates the 21-bp repeats through CREB1 and not other bZIP proteins. The additional transactivation of Tax-responsive promoters subsequent to initiation is also presented. This result highlights a potentially novel role of Tax following TBP recruitment i.e. initiation and may expand the mechanism of Tax transactivation in promoter clearance and transcriptional elongation. Viruses have long been a source of key scientific discoveries. Historically they have contributed to our knowledge of transcription cell cycle and apoptosis. To date activated transcription in higher eukaryotic cells with or without chromatin is a
