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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hepatic expression of multidrug resistance protein 2 in biliary atresia. | Terui et al. Comparative Hepatology 2011 10 6 http www.comparative-hepatology.eom content 10 1 6 COMPARATIVE HEPATOLOGY RESEARCH Open Access Hepatic expression of multidrug resistance protein 2 in biliary atresia Keita Terui Takeshi Saito Tomoro Hishiki Yoshiharu Sato Tetsuya Mitsunaga and Hideo Yoshida Abstract Background Biliary atresia BA is an idiopathic inflammatory obliterative cholangiopathy of neonates leading to progressive biliary cirrhosis. Hepatoportoenterostomy Kasai procedure can cure jaundice in 30 to 80 of patients. Postoperative clearance of jaundice is one of the most important factors influencing long-term outcomes of BA patients. Multidrug resistance protein 2 MRP2 is one of the canalicular export pumps located in hepatocytes it exports organic anions and their conjugates e.g. bilirubin into bile canaliculus. Although MRP2 is an essential transporter for the excretion of bilirubin its role in the clinical course of BA patients is unclear. The present study investigated the relationship between hepatic MRP2 expression and clinical course in BA patients with particular emphasis in curing jaundice after hepatoportoenterostomy. Results No significant differences in hepatic MRP2 expression level were observed between BA and controls groups. There was no correlation between MRP2 expression and age at time of surgery in BA and control groups. In BA patients MRP2 expression level in the jaundice and jaundice-free group did not differ significantly 2.0 X 10-4 vs 3.1 X 10-4 p 0.094 . Although the serum level of total bilirubin just before surgery did not correlate with MRP2 expression level rs 0.031 p 0.914 the serum level of total bilirubin measured at 2 weeks rs -0.569 p 0.034 and 4 weeks after surgery rs -0.620 p 0.018 were significantly correlated with MRP2 expression level. Furthermore MRP2 expression level was inversely correlated with ratio of change in serum total bilirubin level over 4 weeks rs -0.676 p 0.008 which represents the serum bilirubin
