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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Early effect of a single intravenous injection of ethanol on hepatic sinusoidal endothelial fenestrae in rabbits. | Comparative Hepatology BioMed Central Research Early effect of a single intravenous injection of ethanol on hepatic sinusoidal endothelial fenestrae in rabbits Frank Jacobs1 Eddie Wisse2 3 and Bart De Geest 1 Open Access Address 1Center for Molecular and Vascular Biology Department of Molecular and Cellular Medicine University of Leuven Herestraat 49 Leuven 3000 Belgium 2EM Unit Pathology Department University of Maastricht Universiteitssingel 50 Maastricht 6229-ER the Netherlands and 3Department of Internal Medicine University of Maastricht Universiteitssingel 50 Maastricht 6229-ER the Netherlands Email Frank Jacobs - frank.jacobs@med.kuleuven.be Eddie Wisse - eddie@wisse.be Bart De Geest - bart.degeest@med.kuleuven.be Corresponding author Published 13 July 2009 Received 25 March 2009 Comparative Hepatology 2009 8 4 doi 10.1186 1476-5926-8-4 Accepted I3 July 2009 This article is available from http www.comparative-hepatology.cOm content 8 1 4 2009 Jacobs et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background It has been postulated that ethanol affects hepatic sinusoidal and perisinusoidal cells. In the current experimental study we investigated the early effect of a single intravenous dose of ethanol on the diameter of liver sinusoidal endothelial fenestrae in New Zealand White rabbits. The diameter of fenestrae in these rabbits is similar to the diameter found in humans with healthy livers. The effect of ethanol on the size of fenestrae was studied using transmission electron microscopy because plastic embedding provides true measures for the diameter of fenestrae. Results After intravenous administration of a single dose of 0.75 g kg ethanol concentration peaked at 1.1 0.10 g l at ten minutes after .
