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Báo cáo y học: "Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugs. | Comparative Hepatology BioMed Central Open Access Case Report Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugs Sylvie Larrat 1 Marie-Noelle Hilleret2 Raphaele Germi1 Julien Lupo1 Sandrine Nicod1 Jean-Pierre Zarski2 Jean-Marie Seigneurin1 and Patrice Morand1 Address 1Laboratoire de Virologie moléculaire et structurale CHU de Grenoble BP 217 38043 Grenoble cedex 09 France and 2Département d hépatogastroentérologie CHU de Grenoble BP 217 38043 Grenoble cedex 09 France Email Sylvie Larrat - slarrat@chu-grenoble.fr Marie-Noelle Hilleret - mnhilleret@chu-grenoble.fr Raphaele Germi - rgermi@ujf-grenoble.fr Julien Lupo - lupo@embl.fr Sandrine Nicod - snicod@chu-grenoble.fr Jean-Pierre Zarski - jpzarski@chu-grenoble.fr Jean- Marie Seigneurin - JmSeigneurin@chu-grenoble.fr Patrice Morand - PMorand@chu-grenoble.fr Corresponding author Published 12 March 2008 Received 22 August 2007 J. Accepted 12 March 2008 Comparative Hepatology 2008 7 3 doi l0.ll86 l476-5926-7-3 This article is available from http www.comparative-hepatology.cOm content 7 1 3 2008 Larrat et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Sequential monotherapies of nucleotide analogs used in chronic hepatitis B treatment can lead to the selection of a resistance mutation to each antiviral drug. Case presentation A patient with chronic hepatitis B was successively treated with lamivudine monotherapy lamivudine-adefovir dual therapy adefovir monotherapy and again with an adefovir-lamivudine dual therapy. Lamivudine-associated mutations .