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Source: From a study of 347 patients referred to the National Institutes of Health from 1961 to 1977 with a presumptive diagnosis of FUO of 6 months' duration (R Aduan et al. Prolonged fever of unknown origin. Clin Res 26:558A, 1978). More than 200 conditions may be considered in the differential diagnosis of classic FUO in adults; the most common of these are listed in Table 19-3. This list applies strictly to the United States. Geographic considerations are paramount. For example, in Japan, human T cell lymphotropic virus type I is a consideration; in China, infection plays a greater role. | Chapter 019. Fever of Unknown Origin Part 3 Source From a study of 347 patients referred to the National Institutes of Health from 1961 to 1977 with a presumptive diagnosis of FUO of 6 months duration R Aduan et al. Prolonged fever of unknown origin. Clin Res 26 558A 1978 . More than 200 conditions may be considered in the differential diagnosis of classic FUO in adults the most common of these are listed in Table 19-3. This list applies strictly to the United States. Geographic considerations are paramount. For example in Japan human T cell lymphotropic virus type I is a consideration in China infection plays a greater role and tuberculosis is prominent and in Spain visceral leishmaniasis may be a more common cause of FUO. The frequency of global travel underscores the need for a detailed travel history and the continuing emergence of new infectious diseases makes this listing potentially incomplete. The possibility of international and domestic terrorist activity involving the intentional release of infectious agents many of which cause illnesses presenting with prolonged fever underscores the need for obtaining an insightful environmental occupational and professional history with early notification of public health authorities in cases of suspicious etiology Chap. 214 . Table 19-3 Causes of FUO in Adults in the United States Infections Localized pyogenic infections Appendicitis Cat-scratch disease Cholangitis Cholecystitis Dental abscess Diverticulitis abscess Lesser sac abscess Liver abscess Mesenteric lymphadenitis Osteomyelitis Pancreatic abscess Pelvic inflammatory disease Perinephric intrarenal abscess Prostatic abscess Renal malacoplakia Sinusitis Subphrenic abscess Suppurative thrombophlebitis Tuboovarian abscess Intravascular infections Bacterial aortitis Bacterial .
