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- PRP (1970) - Recent technologic advances : the hospital outpatient and ambulatory surgical centers even into physicians’ offices. The following growth factors can be found in the environment of a blood clot: - Transforming growth factor beta (TGF-b) - Platelet-derived growth factor (PDGF) - Insulin-like growth factor (IGF) - Vascular endothelial growth factors (VEGF) - Epidermal growth factor (EGF) - Fibroblast growth factor-2 (FGF-2) | CLINICAL USE OF PLATELET-RICH PLASMA IN ORTHOPAEDICS - PRP (1970) - Recent technologic advances : the hospital outpatient and ambulatory surgical centers even into physicians’ offices. The following growth factors can be found in the environment of a blood clot: - Transforming growth factor beta (TGF-b) - Platelet-derived growth factor (PDGF) - Insulin-like growth factor (IGF) - Vascular endothelial growth factors (VEGF) - Epidermal growth factor (EGF) - Fibroblast growth factor-2 (FGF-2) The repair response: The formation of a blood clot and degranulation of platelets, growth factors and cytokines ( microenvironment) : chemotaxis of inflammatory cells + the activation and proliferation of local progenitor cells fibroblastic scar tissue : a fracture callus, these conditions can also facilitate the formation of new bone tissue. Many of these factors : + osteogenesis ( PDGF, EGF, and FGF-2 : stimulate proliferation of osteoblastic progenitors )(TGF-b increases matrix synthesis (eg, type I collagen) in vitro and in vivo. + Angiogenic factors (VEGF and FGF-2 : angiogenesis and revascularization ) - Enriching a rich environment: +The result is an autologous PRP that contains a biologically active mixture of growth factors without the potential for an immune response. +The effect of the clot microenvironment or concentrates of PDFGs on fracture repair + Clots also contain bone morphogenetic proteins (BMPs). +The growth factors associated with PRP also promote fibroblastic growth, differentiation, and scar formation. The most common applications include: - Tennis elbow (lateral epicondylitis); - Achilles tendonitis (inflammation and swelling of the Achilles tendon); - Patellar tendonitis (inflammation of the patellar tendon, also called "Jumper's Knee"); - Rotator cuff tendonopathy . Tennis elbow (lateral epicondylitis Rotator cuff tendonopathy. Achilles tendonitis (inflammation and swelling of the Achilles tendon) Patellar tendonitis (inflammation of | CLINICAL USE OF PLATELET-RICH PLASMA IN ORTHOPAEDICS - PRP (1970) - Recent technologic advances : the hospital outpatient and ambulatory surgical centers even into physicians’ offices. The following growth factors can be found in the environment of a blood clot: - Transforming growth factor beta (TGF-b) - Platelet-derived growth factor (PDGF) - Insulin-like growth factor (IGF) - Vascular endothelial growth factors (VEGF) - Epidermal growth factor (EGF) - Fibroblast growth factor-2 (FGF-2) The repair response: The formation of a blood clot and degranulation of platelets, growth factors and cytokines ( microenvironment) : chemotaxis of inflammatory cells + the activation and proliferation of local progenitor cells fibroblastic scar tissue : a fracture callus, these conditions can also facilitate the formation of new bone tissue. Many of these factors : + osteogenesis ( PDGF, EGF, and FGF-2 : stimulate proliferation of osteoblastic progenitors )(TGF-b increases matrix
