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Platinum-resistant cases account for 25% of ovarian cancer patients. Our aim was to construct two novel prognostic models based on gene expression data respectively from ferroptosis and necroptosis, for predicting the prognosis of advanced ovarian cancer patients with platinum treatment. | Li et al. BMC Cancer 2022 22 74 https doi.org 10.1186 s12885-021-09166-9 RESEARCH Open Access Two novel prognostic models for ovarian cancer respectively based on ferroptosis and necroptosis Yang Li1 Xiaojin Gong1 Tongxiu Hu1 and Yurong Chen2 Abstract Background Platinum-resistant cases account for 25 of ovarian cancer patients. Our aim was to construct two novel prognostic models based on gene expression data respectively from ferroptosis and necroptosis for predicting the prognosis of advanced ovarian cancer patients with platinum treatment. Methods According to the different overall survivals we screened differentially expressed genes DEGs from 85 ferroptosis-related and 159 necroptosis-related gene expression data in the GSE32062 cohort to establish two ovarian cancer prognostic models based on calculating risk factors of DEGs and log-rank test was used for statistical signifi- cance test of survival data. Subsequently we validated the two models in the GSE26712 cohort and the GSE17260 cohort. In addition we took gene enrichment and microenvironment analyses respectively using limma package and GSVA software to compare the differences between high- and low-risk ovarian cancer patients. Results We constructed two ovarian cancer prognostic models a ferroptosis-related model based on eight-gene expression signature and a necroptosis-related model based on ten-gene expression signature. The two models per- formed well in the GSE26712 cohort but the performance of necroptosis-related model was not well in the GSE17260 cohort. Gene enrichment and microenvironment analyses indicated that the main differences between high- and low- risk ovarian cancer patients occurred in the immune-related indexes including the specific immune cells abun- dance and overall immune indexes. Conclusion In this study ovarian cancer prognostic models based on ferroptosis and necroptosis have been preliminarily validated in predicting prognosis of advanced patients treated with platinum .
