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Studies suggest a high prevalence of pain in head and neck cancer (HNC) patients at diagnosis, during and after treatment; However, these studies had small sample sizes and did not comprehensively assess factors known to influence pain. We surveyed a large cohort of HNC survivors to determine variations in the prevalence of pain, its treatment and management by duration of survivorship, and assessed a comprehensive list of risk factors. | Ren et al. BMC Cancer 2021 21 1304 https doi.org 10.1186 s12885-021-09024-8 RESEARCH Open Access Variations in pain prevalence severity and analgesic use by duration of survivorship a cross-sectional study of 505 post-treatment head and neck cancer survivors Jenny L. Ren1 2 Raniv D. Rojo1 3 Joy Vanessa D. Perez3 Sai Ching J. Yeung1 Ehab Y. Hanna4 and Cielito C. Reyes Gibby1 5 Abstract Background Studies suggest a high prevalence of pain in head and neck cancer HNC patients at diagnosis during and after treatment however these studies had small sample sizes and did not comprehensively assess factors known to influence pain. We surveyed a large cohort of HNC survivors to determine variations in the prevalence of pain its treatment and management by duration of survivorship and assessed a comprehensive list of risk factors. Methods A cross sectional survey of post-treatment survivors of HNC during routine follow-up clinic visits. Results A total of 505 HNC survivors with a median follow up of 3 years from cancer diagnosis were included in the study. Overall 45 n 224 reported pain and 14.5 22 and 7 reported use of prescribed pain medication over- the-counter pain medication and alternative pain therapies respectively. Prevalence of severe pain was 7.3 and did not vary significantly by years of survivorship Ren et al. BMC Cancer 2021 21 1304 Page 2 of 11 head and neck cancer HNC patients at diagnosis 2 8 . by mail using prepared envelopes. The response rate was Pain may also arise as a complication or toxicity of HNC 79.3 . treatment including surgery radiotherapy or chemother- apy. Standard treatment of HNC is based largely on pri- Study variables mary tumor location and cancer stage. Early stage disease Pain severity was assessed with Have you had pain in the is treated with single modality treatment and advanced past week If yes-please indicate how bad your pain has stage disease is treated with multi-modal therapy 9 . been in the last week by marking an X on an .
