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Innovational combination of hetero-bifunctional N-PEG quinoline scaffolds derivatives with improved anticancer activity against breast and colon cancer cell lines and P-glycoprotein, cytochrome p450 enzyme activity prediction

Polyethylene glycol (PEG) is a polymer that is widely used as a carrier for drug delivery systems (DDS). A library of N-PEGylated quinoline derivatives of PEG molecular weight 200 was prepared rapidly after the activation of PEGs using maleic anhydride. Quinoline with a polymer backbone is essential as new material. PEG is a water-soluble nonionic polymer approved by food and drug organizations for medicine applications. Because of its nontoxic grapheme, it is widely utilized in numerous biochemical, cosmetic, pharmaceutical, and industrialized applications. The modern SwissADME is a web tool that stretches free admittance to a pool of hasty, yet solid, clarifying models for physicochemical properties, pharmacokinetics, and therapeutic science. | Turkish Journal of Chemistry Turk J Chem 2020 44 1495-1514 http journals.tubitak.gov.tr chem TÜBİTAK Research Article doi 10.3906 kim-2006-13 Innovational combination of hetero-bifunctional N-PEG quinoline scaffolds derivatives with improved anticancer activity against breast and colon cancer cell lines and P-glycoprotein cytochrome p450 enzyme activity prediction 1 2 3 2 Mahesh GAIDHANE Ajay GHATOLE Kushal LANJEWAR Kishor HATZADE 1 Department of Chemistry Shri Lemdeo Patil Mahavidyalaya RTMNU Mandal MS India 2 Department of Chemistry Dhote Bandhu Science College RTMNU Gondia MS India 3 Department of Chemistry Mohsinbhai Zaweri Mahavidyalaya Desaiganj Wadsa MS India Received 05.06.2020 Accepted Published Online 20.10.2020 Final Version 16.12.2020 Abstract Polyethylene glycol PEG is a polymer that is widely used as a carrier for drug delivery systems DDS . A library of N-PEGylated quinoline derivatives of PEG molecular weight 200 was prepared rapidly after the activation of PEGs using maleic anhydride. Quinoline with a polymer backbone is essential as new material. PEG is a water-soluble nonionic polymer approved by food and drug organizations for medicine applications. Because of its nontoxic grapheme it is widely utilized in numerous biochemical cosmetic pharmaceutical and industrialized applications. The modern SwissADME is a web tool that stretches free admittance to a pool of hasty yet solid clarifying models for physicochemical properties pharmacokinetics and therapeutic science. The present facile synthetic strategy can be a practical approach for incorporating polymeric carriers conjugated with drug moieties either in the backbone of the polymer or as a terminal and pendant group on the polymer chains. Key words PEGylated quinoline breast colon cancer P-glycoprotein cytochrome P450 enzyme 1. Introduction A library of N-polyethylene glycol PEG ylated quinoline derivatives of PEG molecular weight 200 was prepared rapidly after the activation of PEGs using .