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One-pot synthesis of quinazolin-4(3H )-ones and 2,3-dihydroquinazolin-4(1H )-ones utilizing N -(2-aminobenzoyl)benzotriazoles

A convenient and efficient method has emerged for the one-pot synthesis of substituted quinazolin-4(3H)- ones and nonaromatic alkaloids. 2-Substituted quinazolin-4(3H)-ones, 2,3-disubstituted quinazolin-4(3H)-ones, and 2,3-dihydroquinazolin-4(1H)-ones were obtained at yields of 46% to 95% by a one-pot reaction of N -(2-aminobenzoyl) benzotriazoles with amines and orthoesters or aldehydes under catalyst-free conditions. |