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N-Acylazole mediated stereoselective and regioselective synthesis of N-substituted azole acrylonitriles

Regio- and stereoselective synthesis of N-substituted azole acrylonitriles has been achieved smoothly in N, N-dimethylformamide (DMF) in the presence of potassium carbonate (K2CO3) as a base catalyst. N-Substituted azole acrylonitriles were obtained in moderate to good yields (39%–87%) with a one-pot reaction between readily available N-acetylazoles and Baylis-Hillman nitriles. The structural determinations were accomplished by NOESY 1H NMR and X-ray crystallography. |