tailieuchung - Synthesis and biological evaluation of novel chalcones bearing morpholine moiety as antiproliferative agents

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Synthesis and biological evaluation of novel chalcones bearing morpholine moiety as antiproliferative agents

Hiền Mai 54 19 pdf

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In this research, a new series of (E) -3-(4-substitutedphenyl)-1-(4’-morpholinophenyl)prop-2-en-1-one derivatives 1–7 was synthesized, aiming to develop effective antiproliferative agents. The antiproliferative activities of compounds 1–7 were examined against HeLa and C6 cell lines at eight different concentrations using the BrdU ELISA assay. The activity results were compared with reference anticancer drug 5-fluorouracil (5-FU). Compound 1 had almost the same antiproliferative activity as 5-FU. Compounds 1–7 were found to have greater effects against the C6 cell line than the HeLa cell line. |

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