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Bài viết trình bày đánh giá đáp ứng điều trị của phác đồ hóa xạ đồng thời ung thư thanh quản giai đoạn tiến xa tại chỗ tại vùng, đánh giá độc tính điều trị của phác đồ hóa xạ trị đồng thời ung thư thanh quản giai đoạn tiến xa tại chỗ tại vùng. | ĐẦU VÀ CỔ HÓA XẠ TRỊ ĐỒNG THỜI UNG THƯ THANH QUẢN GIAI ĐOẠN TIẾN XA TẠI CHỖ TẠI VÙNG ĐỘC TÍNH ĐÁP ỨNG ĐIỀU TRỊ VÀ KẾT QUẢ SỐNG CÒN BÙI LÊ PHƯỚC THU THẢO1 ĐẶNG HUY QUỐC THỊNH2 LÂM ĐỨC HOÀNG3 ĐẶNG THANH BÌNH4 TRẦN THỊ NGỌC THUẬN5 NGUYỄN THỊ KIM HỒNG6 ABSTRACT Concurrent chemoradiotherapy for advanced stage laryngeal carcinoma Background Primary chemoradiotherapy is considered as a promised alternative option of treatment for patients with advanced laryngeal carcinoma because it can achieve high rate of organ preservation without sacrificing survival compared with radiation alone or conventional laryngectomy. Appropriate selection of patients for organ preservation approaches could enhance overall treatment outcome. We conduct a phase II organ preservation trial to determine the efficacy feasibility and toxicity of Concurrent Chemoradiotherapy CCRT for locally advanced laryngeal carcinoma. Patients and Methods Laryngeal cancer patients had T3 squamous cell carcinoma of the larynx. These patients were technically total laryngectomy resectable. They were given one cycle of induction chemotherapy consisted cisplatin 100mg m on day 1 and fluorouracil 1000mg m day for 4 days. Patients who achieved less than 50 response had immediate laryngectomy. Patients who achieved more than 50 response went on to CCRT with cisplatin 100mg m every 3 weeks for 3 cycles. Patients with residual disease after CCRT had planned salvage surgery. Results Of 53 eligible patients 44 patients 83 achieved more than 50 response and received CCRT and 40 of them completed treatment. Of 40 patients with completion of treatment 32 80 had completed response and one patient had salvage surgery after chemoradiotherapy. The mean follow-up time was 36 6 months and median was 46 months. The overall survival rate at 3 years is 82 . Conclusion In patients with advanced laryngeal carcinoma CCRT has high response rate and high larynx preservation rate with acceptable toxicities. MỤC TIÊU NGHIÊN CỨU Khảo sát khả
