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Glycoprotein based phylogenetic analysis of rabies virus isolates

Glycoprotein of rabies virus is major contributor to pathogenicity. Glycoprotein based phylogenetic analysis of twenty three rabies and rabies related virus including CVS strain was done by aligning the sequences by clustal W. Glycoprotein sequence based phylogenetic tree was constructed and ten conserved motifs were analyzed among these glycoproteins. The unique sequence of motif 4 was observed only in CVS strain (FJ979833) which might be responsible for discriminating CVS strain from other rabies virus strains. The present study might open the possibility of developing strain specific PCR for identification of rabies virus in canids. |