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SIMLIN: A bioinformatics tool for prediction of S-sulphenylation in the human proteome based on multi-stage ensemblelearning models

S-sulphenylation is a ubiquitous protein post-translational modification (PTM) where an S-hydroxyl (−SOH) bond is formed via the reversible oxidation on the Sulfhydryl group of cysteine (C). Recent experimental studies have revealed that S-sulphenylation plays critical roles in many biological functions, such as protein regulation and cell signaling. |