tailieuchung - Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

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Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

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Immunomodulatory drugs (IMiDs), such as lenalidomide, are therapeutically active compounds that bind and modulate the E3 ubiquitin ligase substrate recruiter cereblon, thereby affect steady-state levels of cereblon and cereblon binding partners, such as ikaros and aiolos, and induce many cellular responses, including cytotoxicity to multiple myeloma (MM) cells. |

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Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

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