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Saikosaponin d induces cell death through caspase-3-dependent, caspase-3- independent and mitochondrial pathways in mammalian hepatic stellate cells

Saikosaponin d (SSd) is one of the main active triterpene saponins in Bupleurum falcatum. It has a steroid-like structure, and is reported to have pharmacological activities, including liver protection in rat, cell cycle arrest and apoptosis induction in several cancer cell lines. |