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The clinical factors that accurately predict the response to preoperative treatment in rectal cancer were yet unknown. The carcinoembryonic antigen (CEA) clearance pattern during neoadjuvant treatment has been developed and the predictive value explored in rectal cancer patients with elevated CEA levels (> 5 ng/mL). | CEA clearance pattern as a predictor of tumor response to neoadjuvant treatment in rectal cancer A post-hoc analysis of FOWARC trial