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Cancers of unknown primary origin (CUPs) are reported to be the 3-4th most common causes of cancer death. Recent years have seen advances in mutational analysis and genomics profiling. These advances could improve accuracy of diagnosis of CUPs and might improve the prognosis of patients with CUPs. | Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis A rare case report and literature review