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The present study was carried out in TVCC, Hisar on twenty-four dogs affected with venereal granuloma. Affected dogs were divided equally into three groups viz. vincristine therapy (Group I) with 7 day cycle and doxorubicin therapy consisting two groups i.e. Group IIwith 14 day cycleand group III with 21 day cycle. Blood sample collection was doneat weekly interval and before administration of drug i.e. Day 0,7,14 in Group I, Day 0,7,14,21,28 in Group II and Day 0,7,14,21,28,35,42 in Group III. Kidney Function Tests viz. Creatinine, Blood Urea Nitrogen , Total protein was undertaken for study.Nonsignificant effect of vincristine and doxorubicin recorded on serum total protein. Serum creatinine evidenced decreasing pattern in Group I.Serum creatinine values were slightly elevated till Day 14 and then declined till day 28 in Group II. Non-significant but continuous decreasing pattern was observed in Group III. BUN registered non-significant undulating trend in Group I, non-significant but continuous decreasing pattern in Group II and gradual increasing pattern from Day 7 to Day 28 and distinct drop till Day 42 in Group III. | Study of kidney function tests in pre and post-treated dogs on chemotherapy with doxorubicin and vincristine in venereal granuloma
