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Smurf2 E3 ubiquitin ligase physically associates with and regulate the stability of distinct cellular protein substrates. The multi-functional scaffold protein Connector enhancer of kinase suppressor of ras 2 (CNKSR2) plays a key role in regulating cell proliferation, and differentiation through multiple receptor tyrosine kinase pathways. | Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2 and its role in breast cancer progression
