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Intratumor heterogeneity index of breast carcinomas based on DNA methylation profiles

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Cancer cells evolve and constitute heterogeneous populations that fluctuate in space and time and are subjected to selection generating intratumor heterogeneity. This phenomenon is determined by the acquisition of genetic/epigenetic alterations and their selection over time which has clinical implications on drug resistance. | Intratumor heterogeneity index of breast carcinomas based on DNA methylation profiles

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