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Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells

Glioblastoma multiforme (GBM) is the most severe type of primary brain tumor with a high mortality rate. Although extensive treatments for GBM, including resection, irradiation, chemotherapy and immunotherapy, have been tried, the prognosis is still poor. | Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells