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An environmentally benign aqueous protocol for the synthesis of novel 2-((5-(4-methoxybenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)amino)substituted acid by using potassium carbonate as a base has been achieved. | Green synthesis of 4-methoxybenzylidene thiazole derivatives using potassium carbonate as base under ultrasound irradiation Current Chemistry Letters 8 2019 211 224 Contents lists available at GrowingScience Current Chemistry Letters homepage www.GrowingScience.com Green synthesis of 4-methoxybenzylidene thiazole derivatives using potassium carbonate as base under ultrasound irradiation Dattatraya N. Pansarea Rohini N. Shelkea Chandraknat D. Pawarb Aniket P. Sarkateb Pravin N. Chavanc Shankar R. Thopated and Devanand B. Shindee a Department of Chemistry Deogiri college Station road Aurangabad 431 005 MS India b Department of Chemical Technology Dr. Babasaheb Ambedkar Marathwada University Aurangabad-431 004 MS India c Department of Chemistry Doshi Vakil College Goregaon District-Raigad MS India d Department of Chemistry S.S.G.M. College Kopargaon Ahmednagar MS India e Shivaji University Vidyanagar Kolhapur 416 004 MS India CHRONICLE ABSTRACT Article history An environmentally benign aqueous protocol for the synthesis of novel 2- 5- 4- Received February 26 2019 methoxybenzylidene -4-oxo-4 5-dihydrothiazol-2-yl amino substituted acid by using Received in revised form potassium carbonate as a base has been achieved. These ultrasound irradiation and June 2 2019 conventional technique reaction proceed efficiently in water in the absence of organic solvent. Accepted June 2 2019 In comparison with conventional methods our protocol is convenient and offers several Available online advantages such as shorter reaction time higher yields milder conditions and environmental June 2 2019 friendliness. Keywords 4-Methoxybenzylidene Water Ultrasonic Irradiation Potassium Carbonate 2019 by the authors licensee Growing Science Canada. 1. Introduction The Nitrogen-containing five and six-member heterocyclic compounds and their derivatives which can be easily synthesized in laboratories are particularly important and often found in natural sources. The 2-thioxothiazolidin-4-one .