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A group of new fluoroaniline Schiff bases (3a–3f) were synthesized and structurally characterized by various spectroscopic techniques such as 1H-NMR, LC-MS and FT-IR spectral studies. | Synthesis and characterization of Schiff base analogues of fluoroaniline and their antibiocidal activity against MRSA Current Chemistry Letters 8 2019 169 176 Contents lists available at GrowingScience Current Chemistry Letters homepage www.GrowingScience.com Synthesis and characterization of Schiff base analogues of fluoroaniline and their antibiocidal activity against MRSA M.V. Santhosha b H.S. NagendraPrasada S. Nagashreea H.M. Manukumara L. Malleshac and P. Mallua a Department of Chemistry Sri Jayachamarajendra College of Engineering JSS Science and Technology University Mysuru-570 006 Karnataka India b Department of chemistry GSSS institute of Engineering and Technology for women Mysuru-570016 Karnataka India c PG Department of Chemistry JSS College of Arts Commerce and Science Mysuru-570006 Karnataka India CHRONICLE ABSTRACT Article history A group of new fluoroaniline Schiff bases 3a 3f were synthesized and structurally Received September 18 2018 characterized by various spectroscopic techniques such as 1H-NMR LC-MS and FT-IR Received in revised form spectral studies. All compounds were evaluated for in vitro antibacterial activity. Compounds April 12 2019 exhibited good to moderate antibacterial activity. Compound 3f Zone of Inhibition Accepted April 21 2019 10.08 0.06 µM was found to be the most active one and comparable to the standard Available online Streptomycin IC50 15.95 0.08 µM . The compounds having chloro substituent exhibit good April 22 2019 membrane damage property against Methicillin-resistant Staphylococcus aureus MRSA Keywords confirmed by SEM analysis. Structure-activity relationship SAR was rationalized by looking Schiff base Fluoroaniline at the varying structural features of the molecules. Antibacterial activity MRSA 2019 by the authors licensee Growing Science Canada. 1. Introduction Schiff bases imine or azomethine C N- are formed by condensation of precursors of amine and carbonyl groups1-2. These Schiff bases are having broad .
