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Fusarium wilt being caused by a major vascular pathogen of banana and it is difficult to control once it gets colonized. The present study was aimed at screening the potential endophytic bacteria against the Fusarium pathogen. The pathogen was first isolated from the diseased infected plant and morphologically and molecularly confirmed as Fusarium oxysporum f.sp. cubense (Foc) and its virulence confirmed. The culturable bacterial endophytes were isolated from the Foc-resistant banana cultivar ‘Yangambi km5’ and Foc-susceptible banana cultivar ‘Ney Poovan’. Leaf, petiole, pseudostem, rhizome and root tissue samples were taken for isolation of endophytic bacteria. From the different tissues 38 culturable endophytic bacteria from cv. ‘Yangambi km5’ and 18 culturable endophytic bacteria from cv. ‘Ney Poovan’ were isolated. These isolates were screened against the Foc in order to elucidate their antagonistic potential. The study revealed that banana cultivar ‘Yangambi km5’ hosts twelve antagonist bacterial isolates, out of the thirty-eight isolates, whereas in cv ‘Ney Poovan’ none of the eighteen isolates was found to inhibit pathogenic fungal growth significantly. The study indicated the potential possibility of isolates from Yangambi km5 could play a key role in resisting Fusarial wilt incidence and its vascular development. | In-planta resistance to panama wilt of banana is modulated by endophytic bacteria: A preliminary study supporting the hypothesis